Dyck GB, Shafer SL. Effects of age on propofol pharmacokinetics, Seminars in Anesthesia 11:2-4, 1992.. Glass PS, Hardman D, Kamiyama Y, Quill TJ, Marton G, Donn KH, Grosse CM, Hermann D. Preliminary pharmacokinetics and pharmacodynamics of an ultra-short-acting opioid: remifentanil (GI87084B). Anesth Analg 77:1031-1040, 1993

Pharmacokinetics models with propofol were developed for many species like rats [7,9], pigs [25], dogs [26], cats [27] and rabbits [8,28]. Cockshott and colleagues 

The pharmacokinetics of propofol administered as long term infusions were determined in 12 intensive care unit patients (two female; mean age 58 yr, mean weight 66.9 kg) requiring sedation during mechanical ventilation. Patients were recruited after having been administered propofol for 24 h. Propofol Pharmacokinetics and Pharmacodynamics Modelling The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. 2012-11-04 The pharmacokinetics of propofol in an emulsion formulation ('Diprivan') have been studied after single bolus doses to rats, dogs, rabbits and pigs, and after single and multiple infusions to dogs.

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Nitsun M, Pharmacokinetics of midazolam, propofol and fentanyl transfer to. Profylax som anestesiinduktion med propofol samt betametason A model for size and age changes in the pharmacokinetics of paracetamol. It have been Studied the comparation between lidocaine and metoclopramide in reducing pain on injection during propofol induction in Dr Kariadi General  Översättningar av ord PROPOFOL från engelsk till svenska och exempel på the pharmacokinetics(metabolism and exposure) or the pharmacodynamics(EEG  Uppugunduri S. Pharmacogenetic aspects of tramadol pharmacokinetics and concentrations, clinical signs and EEG during propofol treatment. Basic Clin. of sevoflurane and propofol on the brain - A 3-T magnetic resonance imaging an experimental tool uncovering latent sensitisation: pharmacokinetics in  Call for an Optimised Population Based Pharmacokinetic Model for Propofol. Mats Enlund Dept of Anaesthesia & Intensive Care, and Centre for  SFAI:s riktlinjer för sedering med propofol rekommenderar användande Sahyoun C, Krauss B. Clinical implications of pharmacokinetics and. Hjärtstopp, kramper, takyarytmi.

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Propofol is used to maintain anaesthesia by continuous infusion. Although distributed ex-tensively into tissues, the drug is known to be cleared rapidly and linear pharmacokinetics have been observed with infusion to healthy patients [1].

It have been Studied the comparation between lidocaine and metoclopramide in reducing pain on injection during propofol induction in Dr Kariadi General 

An allometric model using TBW as the size descriptor of volumes and clearances was superior to other size descriptors to characterize propofol PK in obese patients. Keywords: anaesthetics i.v., propofol; obesity; pharmacokinetics Accepted for publication: 17 May 2010 Keywords propofol infusion pharmacokinetics Introduction Early pharmacokinetic studies of the intra-venous anaesthetic agent propofol, administered as a single i.v. bolus dose, have suggested that this agentwaseliminated veryrapidly fromthe body. Thiswasindicatedbyestimates ofelimi-nationhalf-life of1.5-5 handofsystemicclear-ance which exceeded 2021-02-24 · Propofol is known as one of the most potential anesthetics which suffer from limited duration of anesthesia water insolubility. Therefore, in the present study, a formulation of propofol- carboxylic acid-poly [ethylene glycol (COO-PEG)]-b-poly[ D,L lactide (PDLA)]-nanomicelle was developed and its characterization was done by transmission electron microscopy (TEM) and dynamic light scattering Pharmacokinetics of propofol after a single dose in children aged 1-3 years with minor burns. Comparison of three data analysis approaches.

It exerts its effects through potentiation  Propofol: Pharmacokinetics, Medical Uses and Potential Health Effects Several studies have reported analgesic effects of subhypnotic doses of propofol on  11 Jan 2016 Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid -Gestational Fetal Surgery: A Maternal-Fetal Sheep Model. We therefore studied the effects of mild hypothermia on atracurium duration of action, and on propofol pharmacokinetics and hepatic blood flow, in healthy  18 Jul 2018 Elimination and Excretion. After metabolism, 88% of propofol is excreted within 5 days in the urine. Less than 0.3% of administered propofol is  11 Jun 2011 pharmacokinetics < Drugs, child < Age, infant < Age, neonate <. Age The pharmacokinetics of propofol are relatively well-described in the  4 May 2020 This topic will discuss the advantages, adverse effects, dosing, and pharmacokinetics of the IV sedative-hypnotics (propofol, etomidate,  The pharmacokinetic parameters of propofol that have been studied in various animal species are summarized in Table 141-43;45. 2.3.1. Propofol blood  8 Jun 2015 Poor understanding of the pharmacokinetics of target-controlled A variety of pharmacokinetic models for propofol and remifentanil have been  17 Jan 2020 The Effect of UGT1A9, CYP2B6 and CYP2C9 Genes Polymorphism on Propofol Pharmacokinetics in Children Dimitrije Pavlovic, 1 Ivana Budic,  13 Aug 2018 Under 4 h anesthesia with propofol target-controlled infusion in our Regarding the pharmacokinetics of propofol, sex has been reported to  21 Apr 2010 Sedation for gastrointestinal endoscopies is obtained by opioids, benzodiazepines, propofol, ketamine and/or droperidol.
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vid kraftig oro på en intensivvårdsavdelning Human pharmacology of MDMA: pharmacokinetics, metabolism, and  Propofol eller midazolam kan ges vid behov tills den kliniska effekten av Pharmacokinetics and metabolic profiling of 3H-labelled dexmedetomidine in healthy. Performance of Propofol target-controlled infusion models in the obese: pharmacokinetic and pharmacodynamic analysis. Cortinez et.

We have compared the pharmacokinetics of propofol as an infusion in 10 control and 10 patients with cirrhosis. Anaesthesia was induced within 3-4 min during administration of an infusion of propofol 21 mg kg-1 h-1.
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title = "Robust closed-loop control of induction and maintenance of propofol anesthesia in children",. keywords = "general anesthesia, pharmacokinetics, 

Propofol is administered undiluted intravenously by continuous infusion. Propofol should not be given by repeat bolus injection for maintenance of anaesthesia. Dyck GB, Shafer SL. Effects of age on propofol pharmacokinetics, Seminars in Anesthesia 11:2-4, 1992.. Glass PS, Hardman D, Kamiyama Y, Quill TJ, Marton G, Donn KH, Grosse CM, Hermann D. Preliminary pharmacokinetics and pharmacodynamics of an ultra-short-acting opioid: remifentanil (GI87084B). Anesth Analg 77:1031-1040, 1993 Clinical Pharmacokinetics and Pharmacodynamics of Propofol. Propofol is an intravenous hypnotic drug that is used for induction and maintenance of sedation and general anaesthesia.